. Author manuscript; available in PMC: 2009 Sep 1.

Published in final edited form as: Bioorg Med Chem. 2008 Jul 23;16(17):8187–8195. doi: 10.1016/j.bmc.2008.07.044

Table 3.

Inhibition potency, solubility, and toxicity of CFTR inhibitors.

Compound	IC₅₀ (μM)	Solubility in saline (μM)	% Cell viability
Compound	IC₅₀ (μM)	Solubility in saline (μM)	20 μM	50 μM
CFTR_inh-172	0.38 ± 0.04	17	86	not soluble
Tetrazolo-172	0.76 ± 0.2	189	87	73
Oxo-172	1.4 ± 0.2	420	93	91
α-Me-172	8.2 ± 0.4	259	89	72
Pyridine-NO-172	8.7 ± 0.7	264	not determined