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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Gynecol Oncol. 2008 Jul 1;110(3):329–335. doi: 10.1016/j.ygyno.2008.05.008

Table 4.

Escalation, de-escalation schema

Dose
Level		 PPX
mg/m2 		Up to # of
patients		 Next group of patients depend on # with
DLT at current dose		 When 2 DLTs
have occurred
If 0 DLT If 1 DLT If 2 DLTs
−1a 135 3 Stop, Go to
expanded
phase		 Go to −1b Stop Stop, no
feasibility
phase
−1b 135 3 Stop, Go to
expanded
phase		 Stop n/a Stop, no
feasibility
phase
1a 175 3 Go to 2a Go to 1b Stop Go to −1
1b 175 3 Go to 2a Stop n/a Go to −1
2a 210 3 Stop, Go to
expanded
phase		 Go to 2b Stop Stop, Go to
1,feasibility
phase
2b 210 3 Stop, Go to
expanded
phase		 Stop n/a Stop, Go to 1,
feasibility
phase

n/a = not applicable