Table 6.
Drug Cycle |
Conjugated Taxanes (mg/m2) | Unconjugated Paclitaxel (mg/m2) | Carboplatin | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 4 | 1 | 4 | 1 | 4 | |||||||||
Dose | 135 | 175 | 225 | 135 | 175 | 225 | 135 | 175 | 225 | 135 | 175 | 225 | * | * |
Cases | 3 | 5 | 3 | 5 | 2 | 1 | 3 | 5 | 3 | 4 | 2 | 1 | 11 | 8 |
Cmax | ||||||||||||||
mean | 87.0 | 84.7 | 130.7 | 65.4 | 85.2 | 104.0 | 0.32 | 0.42 | 0.47 | 0.29 | 0.29 | 0.50 | 42.4 | 33.3 |
SD | 11.5 | 13.2 | 25.7 | 4.6 | 29.4 | 0.18 | 0.21 | 0.14 | 0.05 | 0.04 | 8.93 | 11.1 | ||
AUC | ||||||||||||||
mean | 953 | 1006 | 2216 | 901 | 1455 | 1995 | 4.07 | 5.18 | 7.19 | 4.16 | 4.05 | 8.79 | 103 | 85.3 |
SD | 361 | 229 | 588 | 139 | 846 | 1.09 | 3.19 | 0.76 | 0.35 | 1.62 | 19.4 | 19.7 | ||
CL | ||||||||||||||
mean | 154 | 180 | 107 | 153 | 145 | 113 | 6.50 | 7.12 | ||||||
SD | 50 | 37 | 33 | 25 | 84 | 1.60 | 2.21 | |||||||
t½,z | ||||||||||||||
mean | 89.2 | 55.3 | 57.7 | 6.75 | 9.05 | 11.3 | 25.7 | 16.1 | 13.4 | 13.9 | 15.2 | 13.9 | 3.16 | 2.88 |
SD | 58.9 | 21.5 | 12.3 | 1.33 | 3.14 | 9.01 | 3.97 | 1.86 | 2.21 | 0.07 | 0.98 | 0.63 | ||
Vz | ||||||||||||||
mean | 21.6 | 14.5 | 9.25 | 1.47 | 1.70 | 1.83 | 29.3 | 28.5 | ||||||
SD | 19.7 | 7.60 | 4.65 | 0.23 | 0.45 | 10.6 | 7.09 | |||||||
Vss | ||||||||||||||
mean | 2.66 | 2.79 | 2.06 | 1.81 | 1.94 | 1.92 | 16.1 | 18.0 | ||||||
SD | 1.86 | 0.82 | 0.40 | 0.12 | 0.62 | 3.53 | 4.76 | |||||||
fe° | ||||||||||||||
mean | 6.01 | 6.40 | 5.83 | 1.27 | 1.97 | 1.80 | 64.0 | |||||||
SD | 1.67 | 1.89 | 0.85 | 0.22 | 0.51 | 0.21 | 14.1 | |||||||
CLR | ||||||||||||||
mean | 9.18 | 12.5 | 7.31 | 508 | 884 | 622 | ||||||||
SD | 0.79 | 5.39 | 2.89 | 112 | 403 | 94.6 |