Table 4.

Abundance changes for several groups of proteins.^a

Swiss-Prot accession #	protein name	ratio in striatumb	ratio in cortex
Glutamate related proteins
P56564	Excitatory amino acid transporter 1	NAc	0.17± 0.06
P43006	Excitatory amino acid transporter 2	NA	0.18± 0.02
Q9D6M3	Mitochondria glutamate carrier 1	1.64± 0.91	0.15± 0.04
P05201	Aspartate aminotransferase	1.17± 0.07	0.33± 0.04
Heat shock proteins
P07901	Heat shock protein HSP 90-alpha	2.40± 1.55	NA
P11499	Heat shock protein HSP 90-beta	3.35± 1.66	1.18± 0.29
P63017	Heat shock cognate 71 kDa protein	1.35± 0.49	0.62± 0.31
P63038	60 kDa heat shock protein	4.40± 2.75	0.24± 0.07
Q64433	10 kDa heat shock protein	2.13± 1.58	1.40± 0.49
Q9CQN1	Heat shock protein 75 kDa	2.57± 1.36	0.86± 0.07
Ubiquitin proteasome system (UPS) related proteins
P62991	Ubiquitin	4.92± 3.39	0.39± 0.11
P61089	Ubiquitin-conjugating enzyme E2	Up	0.41± 0.01
Q7TMY8	E3 ubiquitin protein ligase	down	NA
Q7TQI3	Ubiquitin thiolesterase protein	NA	down
Q9R0P9	Ubiquitin carboxyl-terminal hydrolase isozyme L1	3.01± 1.89	0.38± 0.07
Q9Z2U1	Proteasome subunit alpha type	2.71d	0.38
Synaptic and vesicle related proteins
O08547	Vesicle trafficking protein	NA	Up
O08599	Syntaxin binding protein	3.88± 1.95	0.26± 0.11
O35526	Syntaxin-1A	NA	0.26± 0.06
O88935	Synapsin-1	NA	0.22± 0.12
P46460	Vesicle-fusing ATPase	1.34	0.08± 0.02
P60879	Synaptosomal-associated protein 25	3.37± 1.46	3.55± 2.64
P61264	Syntaxin-1B2	2.33	0.26± 0.10
Q62277	Synaptophysin	3.12	1.04± 0.07
Q64332	Synapsin-2	1.39± 0.38	0.26± 0.06
Q9ER00	Syntaxin-12	NA	0.80
Q9WV55	Vesicle-associated membrane protein-associated protein A	NA	down
Q9QY76	Vesicle-associated membrane protein-associated protein B	NA	0.12

^aThese groups of proteins are believed to bear important biological functions.

^bAbundance ratios are calculated as intensity of R6/2 over WT samples.

^cData not available (proteins not observed).

^dRatios without standard deviations are obtained from a single pair of mice.