Table 1.
Selected microarray results
| Gene symbol | Entrez GeneID | Gene expression ratio (h)a | ||||||
| 2 | 4 | 8 | 12 | 18 | 24 | 72 | ||
| Drug metabolizing enzyme | ||||||||
| Cyp1a1 | 13076 | 1.22 | 1.22 | 1.22 | 2.16 | 1.78 | 1.92 | 1.42 |
| Cyp1a2 | 13077 | 1.16 | 1.26 | 1.30 | 1.61 | 1.50 | 2.29 | 1.30 |
| Cyp2b9 | 13094 | 1.78 | 1.90 | 2.41 | 4.11 | 3.75 | 4.97 | 2.23 |
| Cyp2b10 | 13088 | 2.19 | 2.12 | 2.69 | 11.37 | 12.47 | 18.42 | 4.29 |
| Cyp2b13 | 13089 | 1.49 | 1.36 | 1.46 | 3.79 | 3.54 | 4.09 | 2.04 |
| Cyp2c39 | 13098 | 1.25 | 1.41 | 1.23 | 1.51 | 1.60 | 2.13 | 1.72 |
| Cyp2c55 | 72082 | 1.71 | 3.19 | 7.43 | 15.18 | 30.38 | 36.40 | 7.70 |
| Reductive reaction | ||||||||
| Gsta1 | 14857 | 1.30 | 0.91 | 1.39 | 1.76 | 3.00 | 3.42 | 2.37 |
| Gsta2 | 14858 | 1.53 | 0.83 | 2.23 | 3.52 | 7.01 | 6.60 | 2.91 |
| Gstm2 | 14863 | 1.03 | 1.14 | 2.20 | 2.06 | 2.44 | 3.19 | 1.90 |
| Gstt3 | 103140 | 1.22 | 1.17 | 1.81 | 2.31 | 2.18 | 2.65 | 1.62 |
| Ugt2b35 | 243085 | 1.13 | 1.17 | 1.94 | 2.73 | 2.30 | 3.38 | 2.53 |
| DNA damage/apoptosis | ||||||||
| Casp9 | 12371 | 1.01 | 0.67 | 0.62 | 0.61 | 0.64 | 0.75 | 0.83 |
| Cdkn1a | 12575 | 2.53 | 15.36 | 3.37 | 2.27 | 0.75 | 1.54 | 1.00 |
| Fas | 14102 | 0.94 | 0.89 | 0.78 | 0.80 | 0.85 | 0.66 | 0.72 |
| Gadd45a | 13197 | 2.96 | 12.58 | 13.54 | 8.52 | 3.16 | 1.41 | 2.29 |
| Gadd45b | 17873 | 4.55 | 8.35 | 6.66 | 7.83 | 5.12 | 6.80 | 3.32 |
| Tnfrsf19 | 29820 | 1.22 | 1.75 | 5.86 | 4.29 | 1.67 | 1.66 | 2.21 |
| Metabolism | ||||||||
| ApoA4 | 11808 | 1.15 | 1.05 | 4.31 | 5.03 | 5.74 | 3.54 | 3.34 |
| Ces2 | 234671 | 1.16 | 1.46 | 1.68 | 2.22 | 2.11 | 3.36 | 3.05 |
| Cyp17a1 | 13074 | 1.43 | 1.27 | 3.97 | 6.24 | 5.52 | 3.68 | 1.88 |
| Cyp51 | 13121 | 0.98 | 1.02 | 0.85 | 0.39 | 0.72 | 0.35 | 0.49 |
| Cyp7a1 | 13122 | 1.07 | 0.58 | 0.25 | 0.44 | 0.66 | 0.51 | 1.09 |
| Cyp7b1 | 13123 | 0.98 | 1.51 | 3.05 | 5.77 | 4.15 | 5.44 | 3.41 |
| Insig2 | 72999 | 2.80 | 5.00 | 4.40 | 4.63 | 1.45 | 2.36 | 0.81 |
| Srebf1 | 20787 | 0.94 | 0.51 | 0.31 | 0.21 | 0.70 | 0.47 | 0.31 |
| Cell proliferation | ||||||||
| Ccnb2 | 12442 | 0.94 | 0.84 | 0.82 | 0.49 | 0.68 | 0.86 | 0.83 |
| Ccnd1 | 12443 | 0.71 | 1.17 | 1.08 | 0.85 | 2.32 | 0.78 | 0.66 |
| Ccng2 | 12452 | 1.26 | 1.66 | 1.39 | 0.71 | 0.34 | 1.03 | 0.95 |
| Mdm2 | 17246 | 1.13 | 1.19 | 1.16 | 1.11 | 0.97 | 1.09 | 1.28 |
| Stmn1 | 16765 | 0.74 | 1.00 | 0.69 | 0.35 | 0.59 | 0.84 | 0.60 |
| Oxidative stress | ||||||||
| Gclm | 14630 | 1.06 | 1.15 | 1.36 | 1.54 | 1.33 | 1.59 | 1.50 |
| Gsr | 14782 | 1.02 | 1.40 | 2.03 | 2.47 | 2.39 | 2.54 | 2.33 |
| Hmox2 | 15369 | 1.18 | 1.55 | 1.44 | 1.39 | 1.40 | 1.52 | 1.43 |
| Nqo1 | 18104 | 0.99 | 1.10 | 1.71 | 1.97 | 2.57 | 2.35 | 2.43 |
| Transcription factor/signal transuction | ||||||||
| Ahr | 11622 | 1.20 | 1.43 | 1.29 | 1.50 | 0.96 | 1.47 | 1.15 |
| Nr1i2 (PXR) | 18171 | 1.16 | 1.63 | 1.74 | 1.62 | 1.90 | 1.68 | 1.44 |
| Nr1i3 (CAR) | 12355 | 1.12 | 1.20 | 0.58 | 0.91 | 1.18 | 1.29 | 1.38 |
a Highlighted values indicate expression ratio where p1(t) > 0.999.