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. Author manuscript; available in PMC: 2009 Oct 15.

Published in final edited form as: Biochem Pharmacol. 2008 Aug 7;76(8):967–973. doi: 10.1016/j.bcp.2008.07.036

Secretion of TNF-, IL-1 and production of PGE2, nitrites were significantly attenuated by sulforaphane in the LPS-stimulated Nrf2 (+/+) mouse peritoneal macrophages compared with the LPS-stimulated Nrf2 (−/−) mouse peritoneal macrophages. A: Secretion of TNFα in peritoneal macrophages; B: Secretion of IL-1 in peritoneal macrophages; C: production of PGE2 in peritoneal macrophages; D: production of nitrite in peritoneal macrophages. Columns represent the mean ± SD. The experiments were repeated three times with replicates. One-way ANOVA were used to compare the means between groups. * Significantly different (pÃ0.05) in Nrf2 (+/+) mouse peritoneal macrophages; ∇ significantly different (p<0.05) between Nrf2 (+/+) mouse peritoneal macrophages and Nrf2 (−/−) mouse peritoneal macrophages

Secretion of TNF-, IL-1 and production of PGE2, nitrites were significantly attenuated by sulforaphane in the LPS-stimulated Nrf2 (+/+) mouse peritoneal macrophages compared with the LPS-stimulated Nrf2 (−/−) mouse peritoneal macrophages. A: Secretion of TNFα in peritoneal macrophages; B: Secretion of IL-1 in peritoneal macrophages; C: production of PGE2 in peritoneal macrophages; D: production of nitrite in peritoneal macrophages. Columns represent the mean ± SD. The experiments were repeated three times with replicates. One-way ANOVA were used to compare the means between groups. * Significantly different (pÃ0.05) in Nrf2 (+/+) mouse peritoneal macrophages; ∇ significantly different (p<0.05) between Nrf2 (+/+) mouse peritoneal macrophages and Nrf2 (−/−) mouse peritoneal macrophages