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. 2008 Nov 3;105(45):17498–17503. doi: 10.1073/pnas.0804810105

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© 2008 by The National Academy of Sciences of the USA

Freely available online through the PNAS open access option.

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Fig. 1. — p21 deletion from the Rb^+/−Pttg^−/− background restores pituitary but not thyroid tumor development in mice. (A) Kaplan–Meier survival analysis (log-rank test) of the time of death with evidence of pituitary tumor showed significant differences between Rb^+/−Pttg^−/− and Rb^+/−Pttg^+/+ (P < 0.001), between Rb^+/−Pttg^−/− and Rb^+/+Pttg^−/− (P < 0.05), and between a Rb^+/−Pttg^−/− and Rb^+/−Pttg^−/−p21^−/− mice (P = 0.007). (B) Kaplan–Meier survival analysis (log-rank test) with evidence of thyroid tumors in the different genotypes showed significant differences between Rb^+/−Pttg^−/− and Rb^+/−Pttg^+/+ (P < 0.001), and between Rb^+/−Pttg^+/+ and Rb^+/−Pttg^−/−p21^−/− mice (P < 0.001). No differences were observed between Rb^+/−Pttg^−/− and Rb^+/−Pttg^−/−p21^−/− mice. n, number of animals killed. Western blot analysis of proliferation markers in (C) pituitary and (D) spleen and lung lysates derived from Rb^+/− Pttg^−/− and Rb^+/− Pttg^−/− p21^−/− mice.