. Author manuscript; available in PMC: 2009 Dec 1.

Published in final edited form as: Prostate. 2008 Dec 1;68(16):1806–1815. doi: 10.1002/pros.20848

Table 3.

Multivariate Cox Regression Analysis of Univariately Significant Pathologic Parameters and Biomarkers

Variable	Continuous^†		Dichotomized^‡
Variable	HR (95% CI)	P value	HR (95% CI)	P value
Prostatectomy Gleason Score	2.15 (1.26 – 3.67)	0.005	2.09 (1.21 – 3.62)	0.008
Organ Confined	0.73 (0.14 – 3.70)	0.703	0.71 (0.14 – 3.60)	0.682
Focal Extra-Prostatic Extension	2.04 (0.48 – 8.57)	0.333	1.94 (0.46 – 8.23)	0.370
Non-Focal Extra-Prostatic Extension	1.18 (0.62 – 2.23)	0.622	1.27 (0.70 – 2.31)	0.429
Nuclear Roundness Variance	1.10 (1.03 – 1.19)	0.007	2.98 (1.68 – 5.30)	<0.0001
Her-2/neu	2.73 (1.13 – 6.59)	0.025	2.41 (1.00 – 5.80)	0.049
CD31	1.01 (1.00 – 1.03)	0.085	2.25 (1.1 – 4.64)	0.028
Ki67	1.03 (1.00 – 1.05)	0.027	1.40 (0.83 – 2.38)	0.203

^†

Nuclear Roundness Variance, CD31 and Ki67 were continuous

^‡

All variables were dichotomized