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. Author manuscript; available in PMC: 2008 Nov 3.
Published in final edited form as: Nat Rev Cancer. 2008 May 22;8(8):604–617. doi: 10.1038/nrc2353

Figure 2. Myeloid cells promote angiogenesis.

Figure 2

Myeloid precursor cells adhere to angiogenic endothelium via activated α4β1 or β2 integrins. A variety of tumor or stromal derived factors, including stromal derived factor 1 (SDF-1), colony stimulating factors (CSF), and others mobilize myeloid cells and activate integrins, promoting extravasation into the tumor environment. In the presence of other cytokines and growth factors, these cells differentiate into macrophages, which support tumor growth by expressing VEGF, other pro-angiogenic factors and proteases.