Figure 2.

Comparison of median expression values of the cystic fibrosis (CF) gene signature in preantibiotic (Pre-Rx) and postantibiotic (Post-Rx) peripheral blood mononuclear cell samples versus age- and sex-matched normal control subjects and patients with stable CF. Whiskers on box plots represent range of expression values between patient samples for each individual gene. Median is represented within each box whose boundaries represent the 25th–75th quartiles. Differences in transcript abundance between pre- and post-therapy patients with CF were significant (P < 0.05) for all genes, except for HCA112. *P < 0.05 using analysis of variance with Fisher's protected least significant difference test for difference between bracketed groups.