Figure 4.
Receiver operating characteristic (ROC) curves of gene combinations and FEV1. ROC curves depict the fraction of true-positive (sensitivity) and false-positive (1 − specificity) values plotted for RNA transcripts and FEV1% predicted. A perfect test is indicated by an area under curve = 1. A test with no discriminatory value has an area under curve = 0.50. (A) ROC curves for the development cohort depicting discriminatory capacity of FEV1% predicted alone versus FEV1 with CD64 and ADAM9 transcripts (c-statistic = 0.88). (B) ROC curves for validation group comparing FEV1% predicted alone with FEV1 plus CD64 and CD36 transcripts (c-statistic = 0.80).