TABLE 6.
CYSTIC FIBROSIS PLASMA CYTOKINE LEVELS PRE– AND POST–ANTIBIOTIC THERAPY IN DEVELOPMENT GROUP
| Cytokine | Pre-RX | Post-RX | P Value* |
|---|---|---|---|
| IL-1α | 0.15 ±0.15 | <0.01 | 0.30 |
| IL-1β | 1.09 ± 0.41 | 0.88 ± 0.50 | 0.60 |
| IL-1RA | 2,608 ± 1412 | 1,637 ± 667 | 0.20 |
| IL-2 | 0.95 ± 0.34 | 0.45 ± 0.29 | 0.30 |
| IL-4 | <0.01 | 0.78 ± 0.40 | 0.08 |
| IL-5 | 0.93 ± 0.64 | 0.20 ± 0.11 | 0.08 |
| IL-6 | 7.34 ± 3.39 | 3.57 ± 2.03 | 0.10 |
| IL-8 | 5.37 ± 2.25 | 2.56 ± 1.31 | 0.10 |
| IL-10 | 3.24 ± 2.74 | 1.50 ± 0.55 | 0.90 |
| IL-13 | 1,118 ± 388 | 1,539 ± 495 | 0.30 |
| IL-17 | 2.38 ± 1.36 | 0.15 ± 0.15 | 0.08 |
| TNF-α | 2.99 ± 0.83 | 3.04 ± 0.68 | 0.80 |
| IFN-γ | 0.04 ± 0.04 | 0.37 ± 0.20 | 0.80 |
| G-CSF | 29.50 ± 10.30 | 12.27 ± 4.96 | 0.02 |
| GM-CSF | 0.14 ± 0.08 | 0.45 ± 0.33 | 0.06 |
| MIP-1β | 39.10 ± 13.50 | 31.51 ± 8.83 | 0.20 |
| VEGF | 10.75 ± 2.82 | 10.57 ± 2.76 | 0.50 |
| RANTES | 3216 ± 433 | 4,268 ± 776 | 0.30 |
Definition of abbreviations: G-CSF = granulocyte colony–stimulating factor ; GM-CSF = granulocyte-macrophage colony–stimulating factor ; MIP-1β = macrophage inflammatory protein-1β; Pre-RX = before antibiotic therapy; Post-RX = after antibiotic therapy; RANTES = regulated upon activation, normal T-cell expressed and secreted; TNF-α = tumor necrosis factor-α; VEGF = vascular endothelial growth factor.
Values are mean ± SEM.
*
P values were calculated by paired t test on log-transformed values.