TABLE 7.

DIAGNOSTIC VALUE OF CYSTIC FIBROSIS THERAPEUTIC SIGNATURE FOR RESOLUTION OF AIRWAY INFLAMMATION

	Area under ROC Curve	P Values (logistic regression)
Markers		Gene 1	Gene 2	FEV1
Development cohort
CD64 ADAM9	0.88	0.0003	0.03	0.89
CD64 PLXND1	0.85	0.003	0.01	0.19
CSPG2 ADAM9	0.85	0.01	0.005	0.85
CSPG2 CD163	0.75	0.008	0.03	0.64
FEV1 alone	0.58			0.004
Validation cohort
CD64 CD36	0.8	0.02	0.03	0.5
CD64 CSPG2	0.77	0.02	0.004	0.6
CD64 IL32	0.76	0.03	0.02	0.5
CD36 ADAM9	0.73	0.02	0.03	0.4
FEV1 alone	0.69			0.25

Definition of abbreviations: ROC = receiver operating characteristic.