TABLE 1.
SCHEME OF EXPERIMENT
| No. of Mice Killed
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Regimens* | D −13 | D 0 | Wk 4 | Wk 8 | Wk 10 | Wk 12 | Wk 8 (+3) | Wk 10 (+3)† | Wk 12 (+3) |
| Control animals | |||||||||
| (1) Infected, untreated | 12 | 12 | |||||||
| (2) 8 wk R10HZ + R10H (5/7) | 5 | 5 | 5 | 5 | 15 | ||||
| (3) 8 wk R10HZ + R10H (3/7) | 5 | 5 | 5 | 5 | |||||
| Treatment groups | |||||||||
| Daily | |||||||||
| (4) 8 wk P7.5HZ + P7.5H (5/7) | 5 | 5 | 5 | 5 | 15 | 15 | |||
| (5) 8 wk P10HZ + P10H (5/7) | 5 | 5 | 5 | 15 | 15 | 15 | |||
| (6) 8 wk P10MZ + P10M (5/7) | 5 | 5 | 15 | 15 | |||||
| Thrice-weekly | |||||||||
| (7) 8 wk P10HZ + P10H (3/7) | 5 | 5 | 5 | 5 | 15 | 15 | |||
| (8) 8 wk P15HZ + P15H (3/7) | 5 | 5 | 5 | 15 | 15 | ||||
| (9) 8 wk P20HZ + P20H (3/7) | 5 | 5 | 5 | 15 | 15 | ||||
| (10) 8 wk P15MZ + P15M (3/7) | 5 | 5 | 5 | 15 | 15 | ||||
Definition of abbreviations: H = isoniazid; M = moxifloxacin; P = rifapentine; R = rifampin; Z = pyrazinamide.
*
Drugs were given orally at the following doses: H, 25 and 50 mg/kg when administered daily (5 out of 7 days [5/7]) and thrice-weekly (3/7), respectively; R, 10 mg/kg; Z, 150 and 225 mg/kg when administered 5/7 and 3/7, respectively; M, 100 mg/kg; P, 10, 15, and 20 mg/kg, as indicated.
†
Months 8 (+3), 10 (+3), and 12 (+3) indicate that mice were killed 3 months after completing 8, 10, and 12 months of treatment.