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. Author manuscript; available in PMC: 2009 Oct 16.
Published in final edited form as: Vaccine. 2008 Aug 21;26(44):5554–5561. doi: 10.1016/j.vaccine.2008.08.007

Fig. 3. A 1° and 2° i.n. vaccination provides early complete plague protection.

Fig. 3

Groups of BALB/c mice (n = 8) received a 1° and 2° i.n. vaccination of 2 µg F1, 6 µg V, and 10 µg each CRX-524 and CRX-527 on day 0 and day 10. At various times after the 1° vaccine (day 21 to day 90), groups were challenged intranasally with 100LD50s Y. pestis CO92 (2.3 × 106 CFU) and survival measured at 14 days post challenge.

A: Mice received a 1° and 2° i.n. vaccine on day 0 and day 10 (■); control groups received i.n. F1 + V (Inline graphic), AGPs, or PBS. Only animals receiving the i.n. vaccine were significantly protected (P < 0.0001)

B: Pooled sera total IgG titers against V Inline graphic and F1 Inline graphic were measured in animals one week prior to challenge.