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. Author manuscript; available in PMC: 2009 Feb 1.
Published in final edited form as: Curr Opin Microbiol. 2008 Mar 4;11(1):38–45. doi: 10.1016/j.mib.2008.01.002

Table 1.

Stages of SCV biogenesis

SCV stage Characteristics Host cell markers T3SS effectors implicated References
Early (<30 min) Simple vacuole or spacious phagosome. EEA1, rab5a, rab5b, rab5c, transferrin receptor T3SS1: SipA, SopA, SopB, SpiC/SsaB T3SS2: SpiC [7,27,38,57]
Intermediate (30 min – 5 h) Vacuole primarily in juxtanuclear position Lamps, vATPase, rab7, rab11a, rab11b T3SS1: SopB, SipA T3SS2: SSeF, SseG, SpiC/SsaB, SteC, SseJ/SifC [7,27,57]
Late (>5 h) Initiation of intracellular replication and formation of tubules (Sifs) radiating throughout cells. Microtubule and actin accumulation around juxtanuclear SCV. Lamps, vATPase, rab7, rab9 T3SS2 PipB2, SifA, SopD2, SpiC/SsaB, SseF, SseG, SseJ/SifC, SteC, [20,27,42,48,53,57]