Table 3.
Tat-specific T cell proliferation by MHC class IB haplotype in vaccinated macaques.
| Peak Stimulation indices
|
|||||
|---|---|---|---|---|---|
| Macaque | Pre-challenge | Post-challengea | Pre- challenge | Post-challengea | |
|
H3 Haplotype
|
|||||
| 4014 | 11.4 | 11.4 | |||
| 4015 | 15.9 | 19.3 | |||
| 4017* | 5.3 | 12.9 | |||
| 4021 | 7.7 | 6.7 | H3 mean | 10.2 ± 2.3 | 12.6 ± 2.6 |
|
| |||||
|
H6 Haplotype
|
|||||
| 4004 | 4.7 | 5.2 | |||
| 4008 | 0 | 3.0 | |||
| 4009 | 5.9 | 151.4 | |||
| 4016* | 3.1 | 0 | |||
| 4022* | 12.4 | 0 | |||
| 4023* | 6.5 | 0 | H6 mean | 5.4 ± 1.7 | 26.6 ± 25.0 |
|
| |||||
| H3/H6 mean | 7.3 ± 1.5 | 21.0 ± 14.6 | |||
|
|
|||||
|
Non-H3/H6 Haplotypes
|
|||||
| 4001 | 0 | 0 | |||
| 4002 | 5.5 | 7.7 | |||
| 4007 | 2.9 | 0 | |||
| 4010 | 0 | 0 | |||
| 4011 | 2.0 | 2.9 | |||
| 4013 | 0 | 0 | Non-H3/H6 mean | 1.7 ± 0.9 | 1.8 ± 1.3 |
|
| |||||
| H3/H6 vs Non-H3/H6b | p = 0.011 | ||||
Negative proliferative responses are recorded as 0. Aviremic macaques are marked by an asterisk.
a
Responses weeks 1-8 post-challenge.
b
H3/H6 macaques were combined for this analysis, as proliferative responses did not differ between groups.