Table 4.
The association between genotypes of the COMT, DBH and MAO, A genes and persistent smoking, stratified by sex and smoking intensity in Washington County, Maryland, 1989.
| MEN | WOMEN | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Smoking intensity | Number Current | Number Former | Odds Ratio* | 95% Confidence Interval | Number Current | Number Former | Odds Ratio* | 95% Confidence Interval | ||
| COMT | ≤10 per day | AA/AG | 80 | 257 | 1.0 | 191 | 421 | 1.0 | ||
| GG | 31 | 63 | 1.73† | 1.04, 2.87 | 62 | 127 | 1.08 | 0.76, 1.53 | ||
| 11–29 per day | AA/AG | 229 | 509 | 1.0 | 371 | 336 | 1.0 | |||
| GG | 57 | 156 | 0.88 | 0.61, 1.26 | 118 | 83 | 1.15 | 0.82, 1.60 | ||
| 30≤ per day | AA/AG | 181 | 432 | 1.0 | 154 | 201 | 1.0 | |||
| GG | 54 | 122 | 1.30 | 0.86, 1.96 | 36 | 62 | 0.68 | 0.42, 1.12 | ||
| DBH | ≤10 per day | AA/AG | 78 | 258 | 1.0 | 199 | 436 | 1.0 | ||
| GG | 39 | 82 | 1.59 | 1.00, 2.54 | 66 | 149 | 0.98 | 0.70, 1.38 | ||
| 11–29 per day | AA/AG | 230 | 492 | 1.0 | 382 | 319 | 1.0 | |||
| GG | 68 | 206 | 0.72 | 0.52, 1.00 | 139 | 124 | 0.92 | 0.69, 1.24 | ||
| 30≤ per day | AA/AG | 177 | 433 | 1.0 | 147 | 202 | 1.0 | |||
| GG | 71 | 153 | 1.22 | 0.84, 1.76 | 53 | 72 | 1.01 | 0.65, 1.57 | ||
| MAO-A | ≤10 per day | CO/CC/CT | 87 | 245 | 1.0 | 252 | 530 | 1.0 | ||
| TO/TT | 34 | 93 | 1.00 | 0.63, 1.60 | 18 | 49 | 0.78 | 0.44, 1.36 | ||
| 11–29 per day | CO/CC/CT | 215 | 507 | 1.0 | 482 | 399 | 1.0 | |||
| TO/TT | 79 | 191 | 0.95 | 0.68, 1.31 | 38 | 42 | 0.70 | 0.44, 1.13 | ||
| 30≤ per day | CO/CC/CT | 188 | 429 | 1.0 | 183 | 255 | 1.0 | |||
| TO/TT | 67 | 159 | 1.00 | 0.68, 1.45 | 17 | 23 | 1.12 | 0.56, 2.21 |
*
Analysis adjusted for age
†
Indicates p ≤ 0.05.