Table 3.

Global gene and haplotype associations with MI and ischemic stroke

Genes (haplotypes)	Freq (%)** Control/MI/IS	Myocardial infarction (MI) OR** (95%CI)	Ischemic stroke OR** (95%CI)
CETP
CETP-A	20/18/19	Referent	Referent
CETP-B	14/16/13	1.19 (0.97–1.45)	0.84 (0.64–1.10)
CETP-C	6/5/7	0.92 (0.69–1.22)	0.94 (0.65–1.35)
CETP-D	7/6/5	0.95 (0.70–1.27)	0.77 (0.52–1.14)
CETP-E	6/7/6	1.29 (0.99–1.68)	1.02 (0.68–1.49)
CETP-Others	47/48/50	1.21 (0.99–1.46)	0.87 (0.68–1.15)
	Global Wald test (p-value)§	0.083	0.621
	False discovery rate (q-value)	22%	>50%
IL8
IL8-A	51/53/52	Referent	Referent
IL8-B	42/41/42	0.92 (0.78–1.07)	0.98 (0.78–1.22)
IL8-C	3/3/3	0.99 (0.64–1.54)	0.79 (0.44–1.40)
IL8-Others	3/2/4	1.08 (0.51–2.30)	1.18 (0.54–2.61)
	Global Wald test (p-value)§	0.734	0.812
	False discovery rate (q-value)	>50%	>50%
PPARA
PPARA-A	29/28/27	Referent	Referent
PPARA-B	22/20/21	1.00 (0.80–1.25)	1.03 (0.84–1.27)
PPARA-C	11/19/13	1.82 (1.20–2.77)	1.20 (0.92–1.57)
PPARA-D	9/9/7	1.08 (0.88–1.33)	0.83 (0.61–1.12)
PPARA-E	6/5/7	0.99 (0.75–1.32)	1.25 (0.83–1.89)
PPARA-Others	23/19/25	1.15 (0.79–1.68)	1.08 (0.63–1.87)
	Global Wald test (p-value)§	0.033	0.393
	False discovery rate (q-value)	13%	>50%
TLR4
TLR4-A	27/29/26	Referent	Referent
TLR4-B	22/21/21	0.89 (0.74–1.07)	0.94 (0.72–1.24)
TLR4-C	14/13/15	0.86 (0.67–1.09)	1.08 (0.79–1.49)
TLR4-D	7/5/6	0.60 (0.44–0.82)	0.95 (0.60–1.48)
TLR4-E	6/6/9	0.82 (0.61–1.10)	1.36 (0.90–2.06)
TLR4-F	5/7/5	1.15 (0.82–1.62)	0.98 (0.62–1.54)
TLR4-Others	18/19/19	0.67 (0.48–0.93)	0.88 (0.54–1.43)
	Global Wald test (p-value)§	0.008	0.788
	False discovery rate (q-value)	6%	>50%

^*Probability-weighed haplotype frequencies among controls/myocardial infarction (MI) cases/ischemic stroke (IS) cases.

^**Odds ratios (95%CI) of logistic additive models comparing each haplotype to the referent haplotype adjusted for matching factors (age, sex, race, index year and hypertension status).

^§Global Wald test p-value for overall association of gene with disease.