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. Author manuscript; available in PMC: 2009 Mar 1.
Published in final edited form as: Exp Neurol. 2007 Oct 10;210(1):41–50. doi: 10.1016/j.expneurol.2007.09.027

Figure 2.

Figure 2

Pretreatment with 17α-estradiol significantly attenuates the neonatal muscimol-induced alterations in males (A) and females (C) on the reference memory component of the radial arm maze, and in males (B) and females (D) on the working memory component of the radial arm maze. Consistent with deficits on water maze task, 17β-estradiol was ineffective against the deleterious actions of muscimol. Data represent the mean number of reference memory errors (A and C) (visiting arms that never had food), and working memory errors (B and D) (visiting an arm in which the food was previously consumed) ± SEM values, obtained from three animals in each group. Testing took place over a five day period, with data representing an individual five minute trial performed on a single day.