Figure 3.
Pretreatment with 17α-estradiol attenuated muscimol-induced decrement in hippocampal volume in the (A) male and (B) female rat. Muscimol administration led to a significant decrease in hippocampal volume in males, with the combination of 17β-estradiol + muscimol resulting in further decrement in hippocampal volume in both males and females. In contrast, the hippocampal volumes of animals treated with 17α-estradiol prior to muscimol was equivalent to that of vehicle treated animals. Data represent the mean hippocampal volume (mm3) ± SEM values, obtained from six animals in each group. * indicates significant difference from vehicle treated animals (Tukey; p<0.05). @ indicates significant difference from 17α-estradiol + muscimol treated animals (Tukey; p<0.05).