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. 2008 Nov 12;3(11):e3712. doi: 10.1371/journal.pone.0003712

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Lee et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Receiver operating curves of pGSN levels (solid line) and APACHE III scores (dotted line) identifying 28-day mortality in septic patients are generated. Area under curve is 0.86 for pGSN (95% confidence interval of 0.68–1.05, p = 0.011), and 0.81 for APACHE III (95% confidence interval of 0.60–1.02, p = 0.03. A pGSN level cutoff of <113.6 mg/L yields a 66.7% sensitivity and 93.3% specificity with a likelihood ratio of 10.