Skip to main content
. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Eur J Pharm Biopharm. 2008 Feb 14;69(3):861–870. doi: 10.1016/j.ejpb.2008.02.002

Table 1.

Estimation of stratum corneum thickness (H) by the linear model (LM) and by the simple (S-NL) and baseline corrected (BC-NL) non-linear models for 18 subjects (31 experiments).

Subject1 LM S-NL BC-NL ΔAIC 2 Probability (%) BC-NL is preferred F* / Ftable
H (μm) SER CV (%) H (μm) SER CV (%) H (μm) SER CV (%)
1 a 12.9 0.19 1.5 13.1 0.07 0.6 13.2 0.16 1.2 0.39 45 1.4 / 6.2
1 b * 20.1 0.53 2.7 17.2 0.33 1.9 15.4 0.09 0.6 −37.74 100 101.5 / 56.0
2 a 11.5 0.25 2.2 11.4 0.15 1.3 11.5 0.34 3.0 1.84 29 0.1 / 5.8
2 b 8.8 0.12 1.4 8.5 0.10 1.2 8.0 0.17 2.2 −3.90 88 5.8 / 6.0
3 a * 10.8 0.41 3.8 9.6 0.06 0.6 9.3 0.08 0.8 −10.93 100 14.7 / 5.7
3 b 6.4 0.19 2.9 5.8 0.03 0.5 5.7 0.05 0.8 −2.43 77 4.2 / 6.0
4 10.5 0.25 2.4 10.1 0.06 0.6 9.9 0.13 1.3 −0.88 61 2.6 / 6.0
5 a * 9.9 0.45 4.5 8.5 0.04 0.5 8.4 0.05 0.6 −11.50 100 15.85 / 5.8
5 b * 10.2 0.51 5.0 8.6 0.10 1.2 8.1 0.08 1.0 −18.97 100 33.1 / 6.2
6 * 10.0 0.44 4.4 8.6 0.20 2.3 7.4 0.07 1.0 −32.39 100 91.8 / 6.3
7 * 10.6 0.41 3.8 9.6 0.08 0.8 9.4 0.11 1.2 −4.31 90 6.3 / 6.6
8 a * 7.4 0.29 3.8 6.8 0.07 1.0 6.5 0.05 0.7 −18.50 100 36.6 / 6.8
8 b 13.0 0.37 2.8 11.8 0.14 1.2 11.3 0.16 1.4 −7.19 97 9.9 / 6.1
8 c 10.0 0.20 2.0 9.5 0.04 0.5 9.5 0.08 0.8 1.36 34 0.5 / 9.9
8 d * 7.5 0.28 3.8 6.5 0.17 2.7 5.7 0.05 1.0 −26.04 100 70.5 / 6.7
9 a * 13.0 0.88 6.8 10.4 0.14 1.4 10.0 0.12 1.2 −9.29 99 13.2 / 6.3
9 b 8.8 0.14 1.5 8.7 0.05 0.6 8.8 0.09 1.1 −0.02 50 1.8 / 6.3
9 c 12.4 0.27 2.2 11.7 0.11 0.9 11.2 0.11 1.0 −10.86 100 15.0 / 5.9
10 a 6.4 0.17 2.6 5.9 0.04 0.7 5.7 0.05 0.9 −7.40 98 10.4 / 6.4
10 b * 8.6 0.33 3.9 7.2 0.06 0.9 7.0 0.05 0.7 −12.85 100 19.0 / 6.1
11 6.2 0.16 2.6 6.0 0.04 0.8 6.0 0.09 1.5 0.21 47 1.5 / 6.4
12 a * 13.1 0.38 2.9 11.3 0.10 0.9 10.8 0.07 0.7 −24.33 100 38.5 / 5.7
12 b 14.5 0.24 1.7 15.2 0.06 0.4 15.4 0.10 0.7 −9.18 99 12.6 / 5.9
13 8.1 0.25 3.1 7.6 0.05 0.6 7.6 0.09 1.2 1.76 29 0.2 / 6.2
14 a * 16.2 0.52 3.2 13.9 0.32 2.3 12.0 0.07 0.6 −53.67 100 192.6 / 5.8
14 b * 18.1 0.68 3.8 17.8 0.12 0.7 17.2 0.08 0.5 −25.40 100 56.2 / 6.3
14 c * 9.4 0.27 2.9 9.6 0.16 1.7 10.6 0.66 6.2 −3.41 85 5.3 / 6.0
15 * 12.7 0.27 2.2 12.0 0.11 0.9 11.4 0.13 1.2 −10.28 99 14.2 / 5.9
16 9.1 0.20 2.2 8.5 0.06 0.7 8.4 0.09 1.1 −2.77 80 4.5 / 6.5
17 * 8.8 0.34 3.9 7.5 0.09 1.2 7.1 0.05 0.7 −23.63 100 51.5 / 6.4
18 5.6 0.22 4.0 5.0 0.12 2.4 4.4 0.13 2.8 −7.81 98 11.1 / 6.6
Average 10.7 0.30 3.1 9.8 0.10 1.1 9.5 0.10 1.3 84
H±SD3 10.7 ± 3.4 9.8 ± 3.2 9.5 ± 3.1
1

Cases were a plateau was apparent to the authors are indicated with *.

2

ΔAIC=AICBC-NL – AICS-NL

3

Average H (μm) with standard deviation (SD) for 31 volunteers measured according to the three models.