Table 2.

Significant Changes in Markers Expressed in Various ANKH-Transfectants Relative to that of the neo-Controls at Each Time-Point

Transfectant	ITS	Sox9	Sox5	Sox6	Col2α1	ColX	BSP	MMP-13	ALP Activity	TNAP Protein
ANKH-wt	D0		↑1.4x	↑7.9x	↓5x	↑7.7x
	D10		↓1.7x	↓2x	↓33x		↓10x	↓2.5x
	D17			↓33x		↓2.5x		↓3.3x
	D23		↑1.6x	↓2x		↓10x	↓33x	↓2.5x	↓4x	↓2x
ANKH- ΔE490	D0						↓3.3x
	D10				↓50x	↓10x	↓2.5x	↓3.3x	↓2.8x
	D17	↑9.6x	↑1.9x			↑4.6x	↓3.3x		↓5x	↓2x
	D23	↑2x	↑2.6x	↑3.3x	↑2.5x		↓10x	↓2.5x	↓6x	↓2x