Table 1. Clinical features in affected individuals.
| Case | III.2 | III.3 | III.4 | III.9 | III.11 |
|---|---|---|---|---|---|
| Gender, handedness | M, R | M,NK | M, L | F, R | F, R |
| Age of onset | 65 | 56 | 56 | 58 | 67 |
| Length of history (onset to death) | 7 | 8 | 5 | 5 | N/A |
| First symptoms | Apathy Decreased speech Loss of empathy Sweet tooth Hypersomnia | Apathy Decreased speech Aggression Hypersomnia | Apathy Decreased speech Aggression Sweet tooth | Limb apraxia Dyscalculia Stuttering Anomia Apathy | Anomia Apathy |
| Behavioural features | |||||
| Apathy | + | + | + | + | + |
| Loss of empathy | + | - | + | - | - |
| Disinhibition | + | - | + | - | - |
| Poor judgment | + | + | + | - | - |
| Aggression | + | + | + | - | - |
| Impaired insight | + | + | + | + | + |
| Sweet tooth | + | - | + | + | - |
| Hypersomnia | + | + | - | - | - |
| Language features | |||||
| Decreased quantity of speech | + | + | + | + | + |
| Echolalia | - | - | + | - | - |
| Hesitant or stuttering speech | - | - | - | + | - |
| Anomia | - | - | - | + | + |
| Agrammatism | - | - | - | - | + |
| Phonemic paraphasias | - | - | - | - | + |
| Mutism (years to mutism) | NK | + (4) | + (4) | + (2) | - |
| Other clinical findings | |||||
| Limb apraxia | mild | NK | mild | severe | mild |
| Ideational | - | NK | + | + | + |
| Ideomotor | + | NK | + | + | + |
| Parkinsonism | - | + (late) | + (late) | + (early) | - |
| Symmetry | - | R=L | L>R | L>R | - |
| Rigidity | - | + | + | + | - |
| Bradykinesia | - | - | + | - | - |
| Tremor | - | - | + | + | - |
| Pyramidal signs | - | - | - | + | - |
| Abnormal eye movements | - | - | + | + | - |
| Clinical diagnosis | FTD | FTD | FTD | CBD/PNFA | PNFA |
NK =Not known