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. 2008 Oct 23;27(23):3175–3185. doi: 10.1038/emboj.2008.226

Figure 5.

Figure 5

RhoE phosphorylation by ROCK-I. (A) View of the ROCK-I:RhoE dimer with a substrate peptide based on GSK3β bound to PKB (magenta) (Yang et al, 2002), modelled into the catalytic cleft of ROCK-I. The distance between the visible N and C termini of RhoE to the phosphoacceptor site in ROCK-I is 20 Å. Colour scheme as in Figure 2. (B) Details of the catalytic site of ROCK-I, Fo–Fc electron density (contoured at 3σ in green) overlapping a GSK3β peptide bound to PKB modelled into the ROCK-I catalytic site.