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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Hepatology. 2008 Nov;48(5):1440–1450. doi: 10.1002/hep.22500

Figure 4.

Figure 4

Hepatic parenchymal expression of interferon γ–inducible protein-10 (IP-10/CXCL10) in chronic hepatitis C virus infection with representative hepatic histology. a) Hematoxylin and eosin stain of a representative liver biopsy illustrates portal tract lymphocytic infiltration with extension into the lobular parenchyma (x100). b) CXCL10 is not detected on a liver specimen from an uninfected individual (x200). In chronic HCV-infected patients, CXCL10 is detected primarily in c) lobular hepatocytes (black arrow; x400). d) CXCL10-expressing hepatocytes are localized in an area with heavy lymphocyte infiltration (x400). Dual immunostaining with anti-CXCL10 (red) and anti-CXCR3 (brown) in e) liver parenchyma (x400) and f) periportal (x200) areas reveals co-localization of CXCL10+ hepatocytes with CXCR3+ lymphocytes. CXCL10-expressing hepatocytes are indicated by black arrows (c and e). A CXCR3-expressing lymphocyte is indicated by a white arrow (e).