Table 1.
Demographic characteristics
| Parameter | mRNA1 (N=106) | IHC2 (N=20) | Controls (N=6) | |
|---|---|---|---|---|
| Age3 | 49 (12) | 52.5 (10.0) | 70.5 (6) | |
| Gender | Male | 58 | 12 | 5 |
| Female | 48 | 8 | 1 | |
| Ethnicity | Caucasian | 80 | 13 | 4 |
| AA | 11 | 3 | 0 | |
| Hispanic | 13 | 3 | 1 | |
| Asian | 2 | 1 | 0 | |
| Unknown | 0 | 0 | 1 | |
| Genotype | 1 | 78 | 14 | NA |
| 2–3 | 27 | 5 | NA | |
| Unknown | 1 | 1 | NA | |
| Treatment | Naïve | 86 | 14 | NA |
| Prior NR | 20 | 7 | NA | |
| HCV RNA3,4 International units/ml | 6.0 x 105 (2.4 x 106) | 1.3 x 106 (2.2 x 106) | NA | |
| Portal Grade | 1 | 36 | 4 | NA |
| 2 | 50 | 14 | NA | |
| 3 | 20 | 2 | NA | |
| Lobular Grade | 1 | 63 | 6 | NA |
| 2 | 41 | 10 | NA | |
| 3 | 2 | 4 | NA | |
| Stage | 0 | 13 | 0 | NA |
| 1 | 34 | 3 | NA | |
| 2 | 34 | 10 | NA | |
| 3 | 21 | 6 | NA | |
| 4 | 4 | 1 | NA | |
1
Demographic data on patients who had mRNA chemokine levels assessed in liver tissue.
2
Demographic data on patients who had chemokine measurements based upon immunohistochemical staining of liver sections
3
Median (interquartile range).
4
HCV RNA obtained within a year of the liver biopsy was available for 83 patients in whom chemokine mRNA levels were assessed and in 6 patients who had samples available for immunohistochemistry.
Abbreviations: IHC, immunohistochemistry; AA, African-American; NR, non-responder; NA, not applicable.