Fig. 3.

Hydrogen bonds with backbone. (A) The number of hydrogen bonds formed between backbone and water (black), between backbone and backbone (red), and between backbone and urea (green), respectively, as a function of time. (B) The number of hydrogen bonds as a function of the radius of gyration of the mutant lysozyme. Black is for backbone–water hydrogen bonds, red is for backbone–backbone hydrogen bonds, and green is for backbone–urea hydrogen bonds.