Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A proposed model for the regulation of p53 nuclear export by Thr-55 phosphorylation. In the absence of MDM2, Thr-55 phosphorylation enhances the p53-CRM1 interaction, which leads to nuclear export of p53 in MDM2-null cells. In the presence of MDM2, however, Thr-55 phosphorylation affects the p53-MDM2 interaction, resulting in monoubiquitination of p53, which unmasks p53 NES and promotes CRM1 binding.
