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Model of osteoblastic regulation of B lymphopoiesis. Within the bone marrow of early postnatal mice, B cell precursors are located in close proximity to cells of the osteoblast lineage. Stimulation of Gsα-coupled GPCRs on the osteoblast surface leads to up-regulation of PKA target genes. These may include genes encoding for factors that stimulate B lymphopoiesis, such as IL-7.
