Table 1.
IGF2 DMR methylation among individuals periconceptionally exposed to famine and their unexposed, same-sex siblings
| IGF2 DMR methylation | Mean methylation fraction (SD) |
Relative change exposed | Difference in SDs | P | |||
|---|---|---|---|---|---|---|---|
| Exposed (n = 60) | Controls (n = 60) | ||||||
| Average | 0.488 | (0.047) | 0.515 | (0.055) | −5.2% | −0.48 | 5.9 × 10−5 |
| CpG 1 | 0.436 | (0.037) | 0.470 | (0.041) | −6.9% | −0.78 | 1.5 × 10−4 |
| CpG 2 and 3 | 0.451 | (0.033) | 0.473 | (0.055) | −4.7% | −0.41 | 8.1 × 10−3 |
| CpG 4 | 0.577 | (0.114) | 0.591 | (0.112) | −2.3% | −0.12 | .41 |
| CpG 5 | 0.491 | (0.061) | 0.529 | (0.068) | −7.2% | −0.56 | 1.4 × 10−3 |
P values were obtained using a linear mixed model and adjusted for age.