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Aortic Plg activator (PA) activity. Thoracic aortae of wild-type, Plg KO (Plg−/−), or PAI-1 KO (Serpine1−/−) mice were placed in explant culture. Mice were either hemizygous for the SR-uPA transgene (+/0) or nontransgenic (0/0); all mice were Plau+/+. Culture media were assayed for PA activity using Plg and S-2251. Dots represent individual aortae; bars are group medians.
