Figure 9.

Modeling of DNA fragmentation. Two models of DNA fragmentation were analyzed. Model 1 is based on double-strand breaks. Panel A.1 shows the resulting average fragment sizes that occur over time for an initial fragment length of 1 Mbp, assuming different rates of strand breaks per day. Panel A.2 shows fragment sizes resulting from different initial lengths of DNA, for a rate of two strand breaks per day. Model 2 is based on nicking of single strands in double-stranded DNA. Panel B shows the distribution of fragments resulting from a starting size of 1 Mbp, at a rate of 18 nicks per day.