Table 2.

Study Schedule

	< 48 h	Day 4	day 7	day 14	day 30	5 months	1 year	2 year
Immune response
Response to immunizations						x	x
Cytokine response	x		x	x		x	x
Faecal Calprotectin/IL-8	x		x	x	x	x	x
Postnatal adaptation of the gut
Intestinal permeability	x	x	x
Intestinal microflora	x		x	x	x	x	x
Intestinal viscosity					x	x	x
Long-term outcome
IgE/IgG4	x					x	x
Allergic and infectious diseases							x
Side effects immunizations†
Neurodevelopment							x	x

^†Standardized questionnaires (Preparedness and Response Unit, Centre for Infectious disease Control Netherlands, National Institute for Public Health and the Environment, The Netherlands) after the 1^st, 2^nd, 3^rd and 4^th immunization.