Figure 6.

NJ tree showing the evolutionary relationship between JmjC genes from Human, Arabidopsis and Rice. The tree was constructed using JmjC domain region. Based on both phylogenetic information and domain architecture, 12 subfamilies can be defined. The representative domain architectures of each subfamily are shown next to the tree. JmjC proteins in the same subfamily have conserved regions extend from boundaries of JmjC domain, which are highlighted by dash line box. *: Human JMJD6 and KDM6B do not have additional domain besides JmjC domain. **: Arabidopsis PKDM7A has similar domain architecture to other PKDM7 proteins, but lacks the FYRN and FYRC domains. It is assigned to PKDM7 subfamily based on the phylogenetic tree shown in Fig. 7A.