Table 5.

Comparison between NIP predictions (cut-off 0.2) from rigid-body docking and the experimentally known hot-spot residues

	NIP ≥ 0.2	NIP < 0.2	Total
ΔΔG ≥ 1a	73	95	168
ΔΔG < 1a	34	384	418
Total	107	479	586

^a in kcal.mol^-1