Table 2.

Residues involved in contacts (<4.5 Å) with bepridil

Molecule	Region	Residues
Bep1	N-lobe	F27, I36, L41, V44, M45, L48, M60, I61, V64, V72, F77, M80, M81, S84
	C-lobe	E96, L97, L100
Bep2	N-lobe	F20, A23, I26, F27, F77, M81
	C-lobe	L100, F104, I112, L117, M120, L136, F153, F156, M157
Bep3	N-lobe	M45, M50, P52, E56, M60
	C-lobe	E96, D99, L100, R102, M103

Residues whose side chains form the hydrophobic “cavity” at the bottom of each lobe are underlined. Residues that form salt bridges with the pyrrolidine rings of the bepridils are in boldface.