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. 2008 Nov 14;3(11):e3730. doi: 10.1371/journal.pone.0003730

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Cortese et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Panel A. Biotinylation experiments in HEK293-uPAR cells incubated in the absence or presence of amiloride. Lane 1: background, Lane 2: constitutively internalized uPAR, Lane 3: inhibition by amiloride. Panel B: Amiloride inhibits dose-dependently constitutive uPAR endocytosis measured by the cell cytometry assay. Panel C: 5 mM Amiloride specifically inhibits uPAR and 70kDa-Dextran endocytosis, but not Transferrin receptor endocytosis, as observed by the cell cytometry assay. Panel D: Amiloride specifically inhibits uPAR and CD59 but not LRP-1 endocytosis, as observed by the cell cytometry assay. Panel E: Amiloride inhibits uPAR but not uPA:PAI-1 dependent endocytosis, measured by the cell cytometry assay.