Survival curves, median lifespans, percentage increase compared to control, and sample sizes are as follows. (A): Experiment 1. Median lifespan of: UAS-rpr/d2GAL = 75 days (13.6% increase over UAS-rpr/+ & d2GAL/+ controls, P<0.0001), N = 69; UAS-dilp2RNAiA/d2GAL = 67 days, N = 71; UAS-dilp2RNAiA/+ = 66 days, N = 36; UAS-dilp2RNAiB/d2GAL = 66 days, N = 130; UAS-dilp2RNAiB/+ = 60 days, N = 92; UAS-rpr/+ = 66 days, N = 110; and d2GAL/+ = 66 days, N = 61. (B) Experiment 2. Median lifespan of: UAS-rpr/d2GAL = 81 days (19% increase over UAS-rpr/+ control, P<0.0001), N = 155; UAS-dilp2RNAiA/d2GAL = 76 days, N = 157; UAS-dilp2RNAiA/+ = 73 days, N = 137; UAS-dilp2RNAiB/d2GAL = 71 days, N = 145; UAS-dilp2RNAiB/+ = 69 days, N = 129; UAS-rpr/+ = 68 days, N = 139; and d2GAL/+ = 64 days, N = 153. (C) Experiment 3. Median lifespan of: UAS-rpr/d2GAL = 73 days (12% increase over d2GAL/+ control, P<0.0001), N = 153; UAS-dilp2RNAiA/d2GAL = 68 days, N = 180; UAS-dilp2RNAiA/+ = 67 days, N = 166; UAS-dilp2RNAiB/d2GAL = 65 days, N = 179; UAS-dilp2RNAiB/+ = 67 days, N = 175; UAS-rpr/+ = 59 days, N = 149; and d2GAL/+ = 65 days, N = 169. (D) Fecundity of females from experiment 1 shown in (A). (E) Fecundity of females from experiment 2 shown in (B). Data are shown as mean number of eggs laid per female per day±SEM.