Figure 6.

Effect of YC-1 on human renal cancer xenografts. Mice were injected s.c. with A498 tumour cells. After the tumours reached 80–100 mm³ in size, YC-1 (10–100 mg kg⁻¹) or vehicle (0.5% carboxymethyl cellulose) was orally administered daily for 4 weeks. (a) The s.c. tumour volume of A498 cells exceeded 2000 mm³ in size in the control group. Points represent a mean of data obtained from seven mice. (b) Quantitation of body weight from vehicle- and YC-1-treated mice. Each value represents the mean of at least seven animals. ^**P<0.01 compared with the control group. (c) Protein expression of phospho-JNK1/2 was detected using immunohistochemical analyses as described in Materials and methods. JNK, Jun N-terminal kinase.