Figure 3.

UK371,104 inhibits capsaicin-induced bronchoconstriction and has no effect on blood pressure in the anaesthetized guinea pig. UK371,104 or solvent was administered in solution into the trachea (it) of anaesthetized guinea pigs. At the time points in the graphs above capsaicin was administered i.v. and the effects on lung resistance measured. Blood pressure was recorded just before administration of capsaicin. Values are mean with s.e.m of at least four individual experiments. UK371,104 produced significant inhibition of lung resistance at all time 1–5 h post-administration (P<0.05 unpaired t-test) there was no effect on blood pressure at any dose (P>0.05 unpaired t-test).