Table 4. Multivariate analysis (n=175).
| Variable | HR | 95% CI | P-value |
|---|---|---|---|
| ECOG performance status 2 | 1.79 | 1.16–2.77 | 0.008 |
| Loss of weight >5% | 1.05 | 0.73–1.53 | 0.77 |
| Haemoglobin ⩽11.5 g l−1 | 1.48 | 1.06–2.05 | 0.019 |
| CEA>50 ng ml−1 | 1.86 | 1.21–2.88 | 0.004 |
| Peritoneal metastasis | 1.16 | 0.80–1.68 | 0.41 |
| Number of metastatic sites 3–4 | 1.72 | 1.16–2.53 | 0.006 |
| 5-FU-based first-line chemotherapy | 1.97 | 0.86–3.74 | 0.0733 |
| TTP of the first-line chemotherapy ⩽6 months | 1.97 | 1.39–2.80 | <0.0001 |
5-FU=5-fluorouracil; CI=confidence interval; ECOG=Eastern Cooperative Oncology Group; HR=hazard ratio; TTP=time-to-progression.