Table 3. (A): Results of the GeneChip analysis. The upregulated genes (fold-change >2, P<5%) are listed in the upper part, the downregulated genes in the lower part of the table; (B): Sequence-based and structure-based protein interaction prediction showed four possible interaction partners for KLK6.

Probe set	HGNC symbol	Fold change	P-value
A
Upregulated genes
KLK10@209792_s_at	KLK10	5.2	< 0.01
KLK10@215808_at	KLK10	1.6	0.01
Downregulated genes
KLK13@216670_at	KLK13	−1.7	0.01
KLK3@204583_x_at	KLK3	−6.6	0.03
KLK12@233586_s_at	KLK12	−9.4	< 0.01
KLK12@234316_x_at	KLK12	−10.1	< 0.01
KLK1@216699_s_at	KLK1	−10.2	< 0.01
KLK12@220782_x_at	KLK12	−10.5	< 0.01
KLK15@221462_x_at	KLK15	−15.3	< 0.01
B
Protein 1	Predicted partner	Also known as	Function	Compartment
KLK6	SERPINA3	α-1 antiproteinase	DNA-binding, endopeptidase inhibitor activity, inflammatory response	Extracellular, intracellular, nucleus
	SERPINC1	AT III	Blood coagulation	Extracellular region
	SERPINF2	Pigment epithelium-derived factor	Endopeptidase inhibitor activity, protein-binding, acute phase response	Extracellular region
	SNCA	Synuclein	Anti-apoptosis, central nervous system, development, protein binding	Cytoplasm
KLK10	No interaction partner found