Table 3. Prescriptions for antibiotics in the first year of life in children with leukaemia and matched controls.
|
Any childhood leukaemia
|
Childhood acute lymphoblastic leukaemia
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Cases | Controls | Cases | Controls | |||||
| Prescription | No. (%) | No. (%) | OR (95%CI) | P-value | No. (%) | No. (%) | OR (95%CI) | P-value |
| (n=162) | (n=2125) | (n=112) | (n=1435) | |||||
| At least one prescription for an antibiotic | 84 (52) | 1000 (47) | 1.34 (0.93, 1.94) | 0.11 | 60 (54) | 713 (50) | 1.36 (0.87, 2.13) | 0.17 |
| Antibiotic prescribing frequency | ||||||||
| 0 | 78 (48) | 1125 (53) | 1.00 | 0.11a | 52 (46) | 722 (50) | 1.00 | 0.35a |
| 1–2 | 68 (42) | 737 (35) | 1.45 (0.99, 2.10) | 0.47b | 45 (40) | 509 (35) | 1.41 (0.88, 2.24) | 0.34b |
| ⩾3 | 16 (10) | 263 (12) | 0.98 (0.53, 1.78) | 15 (13) | 204 (14) | 1.22 (0.63, 2.37) | ||
| Mean (s.d.) | 1.0 (1.6) | 1.0 (1.5) | 1.05 (0.95, 1.15)c | 0.48c | 1.2 (1.8) | 1.1 (1.6) | 1.06 (0.95, 1.19)c | 0.33c |
| At least one prescription for chloramphenicol (eareye drops) | 29 (18) | 408 (19) | 0.92 (0.59, 1.42) | 0.72 | 22 (20) | 264 (18) | 1.14 (0.68, 1.90) | 0.63 |
a
Test for difference in odds between categories.
b
Test for trend across categories.
c
Odds of disease per prescription increase and associated P-value.