. Author manuscript; available in PMC: 2008 Nov 5.

Published in final edited form as: J Am Soc Nephrol. 2006 Dec 13;18(1):143–154. doi: 10.1681/ASN.2006030208

Table 1.

Characteristics of Sham, Sham rats treated with ABT-627 (Sham+ ABT), HG, and HG rats treated with ABT-627 (HG+ABT) after 10 weeks of treatment. Excretory data were derived from 24-h urine collections in metabolic cages within 48 h of sacrifice. Plasma samples were obtained under anesthesia immediately prior to sacrifice.

	Sham	Sham+ ABT	HG	HG+ ABT
Body Weight (g)	415±12	434±6	331±7^*	331±7^*
Kidney Weight (g)	1.4±0.1	1.4±0.1	1.9±0.1^*	1.6±0.1
Kidney:Body Weight (mg/g)	3.3±0.2	3.2±0.4	5.6±0.3^*	4.9±0.2^*
Blood [Glucose] (mg/dl)	82±1	93±2	461±16^*	454±11^*
Food Intake (g/day)	14±2	18±1	38±1^*	38±1^*
Water Intake (ml/day)	25±2	27±3	180±12^*	167±16^*
Urine Flow (ml/day)	14±1	18±2	158±10^*	131±17^*
Creatinine Clearance (ml/min)	1.0±0.1	1.2±0.1	1.5±0.1^*	1.3±0.1^*
Plasma [ET-1] (pg/ml)	0.7±0.1	0.9±0.1	0.6±0.1	1.7±0.2^*^#

Values are means ± SEM, n=6–11,

p < 0.05 vs Sham,

p < 0.05 vs HG.