Table 1.
Effects of sulforaphane on “blocking” mechanisms.
| Category | Gene | Change in activity |
|---|---|---|
| Phase 1 enzyme | CYP1A1 | Decrease |
| CYP2B1/2 | Decrease | |
| CYP3A4 | Decrease | |
| CYP4A10 | Increase | |
| CYP4A14 | Increase | |
| CYP39A1 | Increase | |
| Phase 2 enzyme | NQO-1 | Increase |
| GST | Increase | |
| Γ-GCS | Increase | |
| UGT | Increase | |
| Antioxidants | Thioredoxin reductase 1 and 3 | Increase |
| Glutathione peroxidase 3 | Increase | |
| Proteasome subunits | Alpha 1 and 3, beta 5, and 26S | Increase |
| Cell cycle and cell growth | Cyclins D1, E2 and T2 | Increase |
| CDK 4, 7 and 9 | Increase | |
| Stress response | Heat shock proteins 1, 1 alpha, 1 beta, 8 and 105 | Increase |
| Transcription factors | CREB binding protein | Increase |
| Aryl hydrocarbon receptor nuclear translocator-like | Increase |