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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: Hum Reprod. 2007 Oct 23;23(1):216–221. doi: 10.1093/humrep/dem255

Table 2.

Potentially disease-associated FOXO3 sequence variants. These correspond to the subset of sequence variants that are not silent or common in controls, and are indicated by a question mark in Table 1. Grantham scores (Grantham, 1974) were calculated using SAPRED (Ye et al., 2007). Other functional prediction methods were performed with SIFT and Polyphen algorithms (Ng and Henikoff, 2001) (Ramensky et al., 2002).

Variant SIFT prediction SAPRED prediction Polyphen Prediction Grantham Score Clinical Correlation Zygosity
c.280C>T (p.Leu94Phe) 0.13 (tolerated) 0.19 (neutral) 1.062 (benign) 22 PA (0) POF (1) Het
c.1021G>A (p.Ala341Thr) 0.54 (tolerated) 0.46 (neutral) 0.773 (benign) 58 PA (0) POF (1) Het
c.1156C>T (p.Leu386Phe) 0.08 (tolerated) 0.24 (neutral) 1.559 (possibly damaging) 22 PA (0) POF (1) Het