Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1991 Jun;59(6):2189–2191. doi: 10.1128/iai.59.6.2189-2191.1991

Shift of excretory-secretory immunogens of Trypanosoma cruzi during human Chagas' disease.

E E Jazín 1, A O Luquetti 1, A Rassi 1, A C Frasch 1
PMCID: PMC257986  PMID: 1903775

Abstract

We studied secreted-excreted immunogens in human patients infected with Trypanosoma cruzi. A pair of 45- to 55-kDa antigens and a family of shed acute-phase antigens characterized the acute phase, while antibodies against a 160- to 170-kDa immunogen appeared at the chronic phase of the disease.

Full text

PDF
2189

Images in this article

2190Image
on p.2190
2190Image
on p.2190
2190Image
on p.2190
2190Image
on p.2190

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Affranchino J. L., Ibañez C. F., Luquetti A. O., Rassi A., Reyes M. B., Macina R. A., Aslund L., Pettersson U., Frasch A. C. Identification of a Trypanosoma cruzi antigen that is shed during the acute phase of Chagas' disease. Mol Biochem Parasitol. 1989 May 15;34(3):221–228. doi: 10.1016/0166-6851(89)90050-9. [DOI] [PubMed] [Google Scholar]
  2. González Cappa S. M., Katzin A. M., Añasco N., Lajmanovich S. Comparative studies on infectivity and surface carbohydrates of several strains of Trypanosoma cruzi. Medicina (B Aires) 1981;41(5):549–555. [PubMed] [Google Scholar]
  3. Joiner K. A., daSilva W. D., Rimoldi M. T., Hammer C. H., Sher A., Kipnis T. L. Biochemical characterization of a factor produced by trypomastigotes of Trypanosoma cruzi that accelerates the decay of complement C3 convertases. J Biol Chem. 1988 Aug 15;263(23):11327–11335. [PubMed] [Google Scholar]
  4. Krettli A. U., Brener Z. Resistance against Trypanosoma cruzi associated to anti-living trypomastigote antibodies. J Immunol. 1982 May;128(5):2009–2012. [PubMed] [Google Scholar]
  5. Marikovsky M., Arnon R., Fishelson Z. Proteases secreted by transforming schistosomula of Schistosoma mansoni promote resistance to killing by complement. J Immunol. 1988 Jul 1;141(1):273–278. [PubMed] [Google Scholar]
  6. Martins M. S., Hudson L., Krettli A. U., Cançado J. R., Brener Z. Human and mouse sera recognize the same polypeptide associated with immunological resistance to Trypanosoma cruzi infection. Clin Exp Immunol. 1985 Aug;61(2):343–350. [PMC free article] [PubMed] [Google Scholar]
  7. Norris K. A., Harth G., So M. Purification of a Trypanosoma cruzi membrane glycoprotein which elicits lytic antibodies. Infect Immun. 1989 Aug;57(8):2372–2377. doi: 10.1128/iai.57.8.2372-2377.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Ouaissi M. A., Taibi A., Cornette J., Velge P., Marty B., Loyens M., Esteva M., Rizvi F. S., Capron A. Characterization of major surface and excretory-secretory immunogens of Trypanosoma cruzi trypomastigotes and identification of potential protective antigen. Parasitology. 1990 Feb;100(Pt 1):115–124. doi: 10.1017/s0031182000060182. [DOI] [PubMed] [Google Scholar]
  9. Reyes M. B., Lorca M., Muñoz P., Frasch A. C. Fetal IgG specificities against Trypanosoma cruzi antigens in infected newborns. Proc Natl Acad Sci U S A. 1990 Apr;87(7):2846–2850. doi: 10.1073/pnas.87.7.2846. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Rimoldi M. T., Sher A., Heiny S., Lituchy A., Hammer C. H., Joiner K. Developmentally regulated expression by Trypanosoma cruzi of molecules that accelerate the decay of complement C3 convertases. Proc Natl Acad Sci U S A. 1988 Jan;85(1):193–197. doi: 10.1073/pnas.85.1.193. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Schenkman S., Diaz C., Nussenzweig V. Attachment of Trypanosoma cruzi trypomastigotes to receptors at restricted cell surface domains. Exp Parasitol. 1991 Jan;72(1):76–86. doi: 10.1016/0014-4894(91)90123-e. [DOI] [PubMed] [Google Scholar]
  12. Scott M. T., Snary D. Protective immunisation of mice using cell surface glycoprotein from Trypanosoma cruzi. Nature. 1979 Nov 1;282(5734):73–74. doi: 10.1038/282073a0. [DOI] [PubMed] [Google Scholar]
  13. Yoshida N. Trypanosoma cruzi: recognition of trypomastigote surface antigens by lytic antisera from mice resistant to acute infection. Exp Parasitol. 1986 Apr;61(2):184–191. doi: 10.1016/0014-4894(86)90151-7. [DOI] [PubMed] [Google Scholar]
  14. Zweerink H. J., Weston H. D., Andersen O. F., Garber S. S., Hayes E. C. Immunity against infection with Trypanosoma cruzi in mice correlates with presence of antibodies against three trypomastigote polypeptides. Infect Immun. 1984 Dec;46(3):826–830. doi: 10.1128/iai.46.3.826-830.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES