Fig. 3.

Both SJ1–145 and SJ1–170 revert the increase in mEPSC amplitude observed in SJ1-KO neurons. (A) Representative example of mEPSC traces recorded from SJ1-KO neurons expressing GFP alone or GFP together with either SJ1–145 or SJ1–170. (B) Cumulative distributions of mEPSC amplitudes showing that both SJ1–145 and SJ1–170 scale down mEPSC amplitude in SJ1-KO neurons, relative to neurons expressing GFP only. (C) Statistical analysis shows that both mEPSC amplitude and frequency were decreased in neurons expressing either SJ1–145 or SJ1–170 relative to neurons expressing GFP only.